San Francisco 49ers quarterback Jimmy Garoppolo, middle, loses a fumble between Indianapolis Colts defensive tackle DeForest Buckner (99), defensive end Al-Quadin Muhammad (97) and defensive end Kwity Paye, right, who recovered the ball, during the second half of an NFL football game in Santa Clara, Calif., Sunday, Oct. 24, 2021. (AP Photo/Tony Avelar)